Cart
sales@molnova.com
Lanoconazole
CAS No. 101530-10-3
Lanoconazole ( —— )
Catalog No. M25038 CAS No. 101530-10-3
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 68 | In Stock |
|
| 10MG | 116 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLanoconazole
-
NoteResearch use only, not for human use.
-
Brief DescriptionLanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo.
-
DescriptionLanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis. Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppresses TPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2, and inhibited neutrophil infiltration to the inflammation site. Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice.
-
Synonyms——
-
PathwayMicrobiology/Virology
-
TargetFungal
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number101530-10-3
-
Formula Weight319.8
-
Molecular FormulaC14H10ClN3S2
-
Purity>98% (HPLC)
-
SolubilityDMSO : 100 mg/mL (312.67 mM; Need ultrasonic)
-
SMILESN#C/C(N1C=CN=C1)=C2SC(C(C=CC=C3)=C3Cl)CS\2.[(E)]
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Shokoohi GR, et al. In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared with Those of Five Antifungal Drugs against Melanized Fungi and Relatives.Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00635-17.
2. Nakamura A, et al. Anti-inflammatory effect of lanoconazole on 12-O-tetradecanoylphorbol-13-acetate- and 2,4,6-trinitrophenyl chloride-induced skin inflammation in mice.Mycoses. 2020 Feb;63(2):189-196.
3. Furukawa K, et al. Lanoconazole, a new imidazole antimycotic compound, protects MAIDS mice against encephalitis caused by Cryptococcus neoformans.J Antimicrob Chemother. 2000 Sep;46(3):443-50.
molnova catalog
related products
-
Lanoconazole
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo.
-
Fosmanogepix
Fosmanogepix (APX001 prodrug) is a novel antifungal agent.
-
Quilseconazole
A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor.
