Lanoconazole

Research use only, not for human use.

Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo.

Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis. Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppresses TPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2, and inhibited neutrophil infiltration to the inflammation site. Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice.

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Animal Model:BALB/c miceDosage:0.3%-3% dosage Administration:Treatment for earResult:Exhibited an inhibition effect of LCZ on ear swelling induced by topical application of TPA in mice. Animal Model:Four week old C57BL/6 mice infected intraperitoneally with LP-BM5 murine leukaemia virus Dosage:3, 10 or 30 mg/kg Administration:Oral adminstration Result:Inhibited C. neoformans? growth in both normal and C. neoformans?-induced encephalitis MAIDS mice .

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Microbiology/Virology

Fungal

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101530-10-3

319.83

C14H10ClN3S2

>98% (HPLC)

DMSO : 100 mg/mL (312.67 mM; Need ultrasonic)

N#C/C(N1C=CN=C1)=C2SC(C(C=CC=C3)=C3Cl)CS\2.[(E)]

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(-20℃)

With Ice Pack

≥ 2 years